Microbiology, Infectious Diseases and Immunology

WHO WE ARE

We, the scientists at the Institute of Microbiology, Infectious Diseases and Immunology aim to perform groundbreaking research into the interactions between microorganisms and the innate immune system, in particular at border surfaces with the environment. We are eager to open new frontiers for research and approach unresolved issues in microbiology, infectious diseases, immunology and epithelial cell biology. Barrier surfaces such as those of the skin, intestine and lungs are continuously exposed to the environment. For example, they are densely colonized by complex consortia of bacteria, fungi, viruses and parasites and are in contact with a multitude of environmental factors (e.g., diets, light, UV irradiation).

We hypothesize that over millions of years of co-evolution of multicellular organisms with their environments, signaling networks involving components of the innate immune system have been selected that are believed to shield the host against continuous threats to its integrity and, thereby, improve its fitness, a process often referred to as adaptation.

We postulate that the recent dramatic increase of immune-mediated diseases (e.g., inflammatory bowel diseases, allergies, multiple sclerosis, metabolic diseases) reflects unsuccessful adaptation of the immune system to the environment. The mission of the Institute is to establish a multidisciplinary center of excellence for research on host-microbe and host-environment interactions. The new insights gained should fundamentally change our scientific thinking and may substantially contribute to future medical practice to prevent infectious and immune-mediated diseases.

Find here the latest Publications

Guendel F, Kofoed-Branzk M, Gronke K, Tizian C, Witkowski M,…, Diefenbach A.
Immunity. 17 November 2020; Volume 53, Issue 5,  Pages 1015-1032.e8 
Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues
Cosovanu C and Neumann C. 
Front.Immunol. 20 October 2020
https://doi.org/10.3389/fimmu.2020.600973
The Many Functions of Foxp3+ Regulatory T Cells in the Intestine
Barrientos G, …, Conrad ML
Sci Rep. 2020; 10: 15243. Published online 2020 Sep 17
Changes in subclass-specific IgG Fc glycosylation associated with the postnatal maturation of the murine immune system
Schaupp L et al.
Cell. Article in press, available online 6 May 2020
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

 BIH paper of the month                       May 2020  
Diefenbach A, Gnafakis S, Shomrat O.
Immunity. 2020 Mar 17
Innate Lymphoid Cell-Epithelial Cell Modules Sustain Intestinal Homeostasis
Alhasan M, Conrad ML, Heimesaat M,
Bereswill S et al.
Allergy. Epub Feb 2020, print August 2020
Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner.

What we do

» Development and Function of the Innate Immune Sytem                                                        » Mucosal Immunology
» Crosstalk between the Nervous and the Immune System                  » Role of the Microbota in Health and Disease
» Gastrointestinal Microbiology                                                                                          » Reproductive Immunology
» Biofilm Formation                                                                                                                      » Molecular Mycology
» Infection Epidemiology                                                                                                                    » Host Septomics
                                                                                                                                                      »Immunometabolism

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3 ERC Grantees
1 Emmy-Noether-Program Recipient

DFG Priority Program
“SPP 1937 on Innate Lymphoid Cells”

Web of Science
Highly Cited Researcher

RESEARCH GROUPS

and Projects

Conrad Lab

Reproductive Immunology

Diefenbach Lab

Development and function of the innate immune system

Dürr Lab

Mucosal Immunity

Gräser Lab

Molecular Mycology

Heimesaat and Bereswill Lab

Gastrointestinal Microbiology

Hamann Lab

Genetic variance within the innate immune system

Jordan Lab

Laboratory of Microbiology, Metabolism & Inflammation (LoMMI)

Klose Lab

Neuro-immune Interactions

Moter Lab

Biofilmcenter

Neumann Lab

Lymphocyte Biology and Microenvironment

Stamatiades Lab

Tissue Monitoring by Macrophages

Triantafyllopoulou Lab

Innate Immunity in Rheumatic Diseases

Feldmeier Lab (affiliated)

Neglected Tropical Diseases

Schumann Lab (affiliated)

Host-Pathogen Interaction

Slevogt Lab (affiliated)

Host Septomics

NEWS and EVENTS

Talk: Giuseppe Sciumè

General and Clinical Pathology at the Department of Molecular Medicine, Sapienza University of Rome, Italy. Virtual Seminar Series 2021 Title: JAK/STAT signals underlying innate lymphoid cell homeostasis and activation When:[…]

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Talk: David Schneider

Department of Microbiology and Immunology, Stanford University CBF Virtual Seminar Series 2021 Title: “Measuring the shape of health” When: Monday, February 22, 2021 at 5:15 pm (17:15 Uhr) Host: Prof.[…]

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Talk: Jakob von Moltke

Assistant Professor, Department of Immunology, University of Washington CBF Virtual Seminar Series 2021 Title of the Talk: “Intestinal Tuft Cells: sentinels and effectors of type 2 immunity” When: February 8th,[…]

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Our Team

View Our Team

FUNDING

Contact us

We are always interested in applications from master and PhD students

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