Slevogt Lab – Affiliated Scientist

Host Septomics

Prof. Dr. med. Hortense Slevogt
Prof. Dr. med. Hortense Slevogt
PI Host Septomics

Jena University Hospital

hortense.slevogt(at)charite.de

+49 3641 9-396520

https://www.septomics.de/de/host-septomics.html

Host Septomicsresearch group for infection and microbiom research” analyses the mechanism of the innate immune response of the host to microbial associated infections on cellular and molecular level. A special focus is placed on the acute and chronical infections of airways and the lung. Different aspects of the complex interaction between pathogens, microbiome and various immune cells are characterised and analysed with cutting-edge methods of next generation sequencing, mass spectrometry as well as molecular biology. We aim to identify new clinical parameters for the diagnosis and the follow-up of pulmonary inflammation as well as the development of new therapeutic strategies.


PROJECTS

Running projecs at Charité:

  • InfectControl 2020: KARMIN, „Krankenhaus-ARchitektur, Mikrobiom und INfektionen im Krankenhaus“ Hospital architecture, microbiome and hospital infections (In collaboration with Prof. Dr. Petra Gastmeier, Institute of Hygiene and Environmental Medicine)

 

  • InfectControl 2020: CLIP-ID-TV4: „The impact of climate changes on the occurrence of infections in Germany and studies on decolonization” (In collaboration with Prof. Dr. Petra Gastmeier, Institute of Hygiene and Environmental Medicine)

 

  • In application: The role of Moraxella catarrhalis and Haemophilus influenza for the reprogramming of human airway epithelium in chronic obstructive lung disease

 


LAB MEMBERS

Frauke Schreiber
Frauke Schreiber
Technical Assistant

frauke.schreiber(at)charite.de

+49 (0)30 450 524 024

 

PUBLICATIONS

Saraiva JP, Oswald M, Biering A, Röll D, Assmann C, Klassert T, Blaess M, Czakai K, Claus R, Löffler J, Slevogt H, König R (2017) Fungal biomarker discovery by integration of classifiers. BMC Genomics. 2017 Aug 10;18(1):601. doi: 0.1186/s12864-017-4006-x.

Schauer AE, Klassert TE, von Lachner C, Riebold D, Schneeweiß A, Stock M, Müller MM, Hammerschmidt S, Bufler P, Seifert U, Dietert K, Dinarello CA, Nold MF, Gruber AD, Nold-Petry CA, Slevogt H (2017) IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia. J Innate Immun. 2017 Jun 10. doi: 10.1159/000469661. [Epub ahead of print]

Müller MM, Lehmann R, Klassert TE, Reifenstein S, Conrad T, Moore C, Kuhn A, Behnert A, Guthke R, Driesch D, Slevogt H (2017) Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression. Sci Rep. 7: 838.

Klaile E, Müller MM, Schäfer MR, Clauder AK, Feer S, Heyl KA, Stock M, Klassert TE, Zipfel PF, Singer BB, Slevogt H (2017) Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells. MBio 8(2). pii: e02142-16. doi: 10.1128/mBio.02142-16. 

Huang N, Kny M, Riediger F, Busch K, Schmidt S, Luft FC, Slevogt H, Fielitz J (2017) Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy. Intensive Care Med Exp 5(1):3. doi: 10.1186/s40635-016-0115-0.

Riege K, Hölzer M, Klassert TE, Barth E, Bräuer J, Collatz M, Hufsky F, Mostajo N, Stock M, Vogel B, Slevogt H, Marz M (2017) Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D. Sci Rep 7:40598. doi: 10.1038/srep40598.

Klassert TE, Bräuer J, Hölzer M, Stock M, Riege K, Zubiría-Barrera C, Müller MM, Rummler S, Skerka C, Marz M, Slevogt H (2017) Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection. Sci Rep 7:40599. doi: 10.1038/srep40599.

Tominski D, Katchanov J, Driesch D, Daley MB, Liedtke A, Schneider A, Slevogt H, Arastéh K, Stocker H (2017) The late-presenting HIV-infected patient 30 years after the introduction of HIV testing: spectrum of opportunistic diseases and missed opportunities for early diagnosis. HIV Med 18(2):125-132. doi: 10.1111/hiv.12403.