Klose Lab

Neuro-immune Interactions

Dr. Christoph Klose
Dr. Christoph Klose
PI Neuro-immune Interactions

christoph.klose(at)charite.de

+49 (0)30 450 524 364

Projects

The nervous system and the immune system are the two large sensory units of the body, which perpetually monitor tissue integrity and mount effector responses upon disturbance of tissue hemostasis. However, how these two sensory systems exchange information and coordinate tissue protective responses remains elusive. Our research has recently exposed signaling pathways, by which the nervous system regulates innate lymphoid cells (ILCs) and type 2 immune responses via the production of neuropeptides (neuromedin U) and neurotransmitters (norepinephrine). ILCs are an emerging population of tissue-resident innate immune cells enriched at mucosal barriers, which can mount either protective or detrimental immune response at barrier surfaces. While we begin to understand some of the tissue-specific cues, which regulate immune activation at barrier surfaces, neuronal regulation of immune responses is still almost a black box. In order to systematically investigate neuro-immune crosstalk at mucosal surfaces in health and disease, we have developed elegant genetic tools, which allow experimental manipulation of neurons and ILCs. Taken together, combing cutting-edge technologies in the fields of immunology, neuroscience and genomics, will enable us to conceptually understand neuro-immune interaction and uncover signaling pathways that have the potential to be therapeutically harnessed.

Lab Members

Anna Savvopoulou
Anna Savvopoulou
Bachelor student

anna.savvopoulou(at)charite.de

Karoline Troch
Karoline Troch
MD student

karoline.troch(at)charite.de

Kiana J. Karbasiyan
Kiana J. Karbasiyan
Bachelor student

kiana.karbasiyan(at)charite.de

Xuemei Gao
Xuemei Gao
PhD student
Dr. Pierre Leclère
Dr. Pierre Leclère
Postdoc
Laura Bartel
Laura Bartel
MD student

laura.bartel(at)charite.de

Ralitsa Moynova
Ralitsa Moynova
Bachelor student

ralitsa.moynova(at)charite.de

Asmaa Zahran
Asmaa Zahran
Master student

asmaa.zahran(at)charite.de

Alexandra Preußer
Alexandra Preußer
Master student

alexandra.preusser(at)charite.de

Laura Paul
Laura Paul
Technical Assitant

laura.paul(at)charite.de

Sotiria Boulekou
Sotiria Boulekou
PhD student

sotiria.boulekou(at)charite.de

Dr. Katja Julika Jarick
Dr. Katja Julika Jarick
Postdoc

katja.jarick(at)charite.de

Dr. Divija D. Deshpande
Dr. Divija D. Deshpande
Postdoc

divija.deshpande(at)charite.de

+49 30 450 524359

Patrycja Topczewska
Patrycja Topczewska
PhD student

+40 30 524 234

Dr. Manuel Jakob
Dr. Manuel Jakob
Postdoc

+49 30 450 524 357

Vladislava Stokic-Trtica
Vladislava Stokic-Trtica
PhD student

vladislava.stokic-trtica(at)charite.de

+49 (0)30 450 524 234

Publications

1. Gronke K., P.P. Hernandez, J. Zimmermann, C.S.N. Klose, M. Kofoed-Branzk, F. Guendel, M. Witkowski, C. Tizian, L. Amann, F. Schumacher, H. Glatt, A. Triantafyllopoulou, A. Diefenbach
Nature, 566:249-253
2019
2. C.S.N. Klose, D. Artis
Current opinion in immunology, 56:94-99
2018
3. C. Chu, S. Moriyama, Z. Li, L. Zhou, A.L. Flamar, C.S.N. Klose, J.B. Moeller, G.G. Putzel, D.R. Withers, G.F. Sonnenberg, D. Artis
Cell reports, 23, 3750-3758
2018