Klose Lab
Neuro-immune Interactions
Projects
The nervous system and the immune system are the two large sensory units of the body, which perpetually monitor tissue integrity and mount effector responses upon disturbance of tissue hemostasis. However, how these two sensory systems exchange information and coordinate tissue protective responses remains elusive. Our research has recently exposed signaling pathways, by which the nervous system regulates innate lymphoid cells (ILCs) and type 2 immune responses via the production of neuropeptides (neuromedin U) and neurotransmitters (norepinephrine). ILCs are an emerging population of tissue-resident innate immune cells enriched at mucosal barriers, which can mount either protective or detrimental immune response at barrier surfaces. While we begin to understand some of the tissue-specific cues, which regulate immune activation at barrier surfaces, neuronal regulation of immune responses is still almost a black box. In order to systematically investigate neuro-immune crosstalk at mucosal surfaces in health and disease, we have developed elegant genetic tools, which allow experimental manipulation of neurons and ILCs. Taken together, combing cutting-edge technologies in the fields of immunology, neuroscience and genomics, will enable us to conceptually understand neuro-immune interaction and uncover signaling pathways that have the potential to be therapeutically harnessed.
Lab Members
Karoline Troch
MD student
karoline.troch(at)charite.de
Xuemei Gao
PhD student
xuemei.gao(at)charite.de
Dr. Pierre Leclère
Postdoc
pierre.leclere(at)charite.de
Alexandra Preußer
Master student
alexandra.preusser(at)charite.de
Sotiria Boulekou
PhD student
sotiria.boulekou(at)charite.de
Dr. Katja Julika Jarick
Postdoc
katja.jarick(at)charite.de
Dr. Divija D. Deshpande
Postdoc
divija.deshpande(at)charite.de
+49 30 450 524359
Patrycja Topczewska
PhD student
+40 30 524 234
Dr. Manuel Jakob
Postdoc
+49 30 450 524 357
Vladislava Stokic-Trtica
PhD student
vladislava.stokic-trtica(at)charite.de
+49 (0)30 450 524 234
Publications
1. Gronke K., P.P. Hernandez, J. Zimmermann, C.S.N. Klose, M. Kofoed-Branzk, F. Guendel, M. Witkowski, C. Tizian, L. Amann, F. Schumacher, H. Glatt, A. Triantafyllopoulou, A. Diefenbach
Nature, 566:249-253
2019
2. C.S.N. Klose, D. Artis
Current opinion in immunology, 56:94-99
2018
3. C. Chu, S. Moriyama, Z. Li, L. Zhou, A.L. Flamar, C.S.N. Klose, J.B. Moeller, G.G. Putzel, D.R. Withers, G.F. Sonnenberg, D. Artis
Cell reports, 23, 3750-3758
2018