Hamann Lab

Mucosal Immunity

Dr. Lutz Hamann
Dr. Lutz Hamann
PI Genetic variance within the innate immune system


+49 (0)30 450 524 232


Innate immune response and healthy aging

Aging is a multifactorial process resulting in accumulation of cellular damage, finally followed by the onset of aging-related diseases such as cardiovascular diseases, chronic lung diseases, cancer, and several more. One characteristic trait of the elderly is a chronically low level of inflammation, called inflamm-aging, that has been associated with the onset of aging-related diseases. Genetic variations that alter the innate immune response are not only associated with combating infectious diseases but also influence the onset of aging-related diseases. Our hypothesis is that genetic variations that impair innate immune response may be positively associated with healthy aging, thereby providing an example for antagonistic pleiotropy.

Lab Members

Christoph Kleinle
Christoph Kleinle
PhD student