Genetic variance within the innate immune system
Innate immune response and healthy aging
Aging is a multifactorial process resulting in accumulation of cellular damage, finally followed by the onset of aging-related diseases such as cardiovascular diseases, chronic lung diseases, cancer, and several more. One characteristic trait of the elderly is a chronically low level of inflammation, called inflamm-aging, that has been associated with the onset of aging-related diseases. Genetic variations that alter the innate immune response are not only associated with combating infectious diseases but also influence the onset of aging-related diseases. Our hypothesis is that genetic variations that impair innate immune response may be positively associated with healthy aging, thereby providing an example for antagonistic pleiotropy.
Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L: The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele. Journal of immunology 2017, 198(2):776-787.
Bustami J, Sukiasyan A, Kupcinskas J, Skieceviciene J, Iakoubov L, Szwed M, Kleinle C, Schumann RR, Puzianowska-Kuznicka M, Hamann L: Cholesteryl ester transfer protein (CETP) I405V polymorphism and cardiovascular disease in eastern European Caucasians – a cross-sectional study. BMC geriatrics 2016, 16:144.
Hallau J, Hamann L, Schumann RR, Worm M, Heine G: A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults. Acta dermato-venereologica 2016, 96(2):169-172.
Hamann L, Bustami J, Iakoubov L, Szwed M, Mossakowska M, Schumann RR, Puzianowska-Kuznicka M: TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians – A cohort study. Immunity & ageing: I & A 2016, 13:7.
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van der Ploeg AH, Kumpf O, Seelow E, Almanza LC, Schlag PM, Schumann RR, Hamann L: The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1beta. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2015, 18(1):77-83.
Hamann L, Glaeser C, Schulz S, Gross M, Franke A, Nothlings U, Schumann RR: A micro RNA-146a polymorphism is associated with coronary restenosis. International journal of immunogenetics 2014, 41(5):393-396.
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Hamann L, Koch A, Sur S, Hoefer N, Glaeser C, Schulz S, Gross M, Franke A, Nothlings U, Zacharowski K et al: Association of a common TLR-6 polymorphism with coronary artery disease – implications for healthy ageing? Immunity & ageing : I & A 2013, 10(1):43.
Heine G, Hoefer N, Franke A, Nothling U, Schumann RR, Hamann L, Worm M: Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults. The British journal of dermatology 2013, 168(4):855-858.
Yang CA, Scheibenbogen C, Bauer S, Kleinle C, Wex T, Bornschein J, Malfertheiner P, Hellmig S, Schumann RR, Hamann L: A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-gamma production and is associated with Helicobacter pylori-induced gastric disease. Helicobacter 2013, 18(1):13-21.
Weitzel T, Zulantay I, Danquah I, Hamann L, Schumann RR, Apt W, Mockenhaupt FP: Mannose-binding lectin and Toll-like receptor polymorphisms and Chagas disease in Chile. The American journal of tropical medicine and hygiene 2012, 86(2):229-232.
Yang CA, Raftery MJ, Hamann L, Guerreiro M, Grutz G, Haase D, Unterwalder N, Schonrich G, Schumann RR, Volk HD et al: Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis. Human immunology 2012, 73(8):844-851.