Conrad Lab - Institute of Microbiology, Infectious Diseases and Immunology

Reproductive Immunology

PROJECT

Prenatal influences on the development of offspring asthma

Our group is specialized in reproductive immunology and allergy; we study how influences during pregnancy such as prenatal exposure to antibiotics, maternal asthma or non-pathogenic bacteria, affect fetal and neonatal development as well as disease susceptibility in early life. For more information about our current projects, please see www.conradlab.net

LAB MEMBERS

PUBLICATIONS

Changes in subclass-specific IgG Fc glycosylation associated with the postnatal maturation of the murine immune system.

Barrientos G, Habazin S, Novokmet M, Almousa Y, Lauc G, Conrad ML.Sci Rep. 2020 Sep 17;10(1):15243. doi: 10.1038/s41598-020-71899-7.https://pubmed.ncbi.nlm.nih.gov/32943699/

Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner.

Alhasan MM, Cait AM, Heimesaat MM, Blaut M, Klopfleisch R, Wedel A, Conlon TM, Yildirim AÖ, Sodemann EB, Mohn WW, Bereswill S, Conrad ML.Allergy. 2020 Aug;75(8):1979-1990. doi: 10.1111/all.14234. Epub 2020 Mar 11.

Maternal asthma is associated with persistent changes in allergic offspring antibody glycosylation.

Sodemann EB, Dähling S, Klopfleisch R, Boiarina E, Cataldo D, Alhasan MM, Yildirim AÖ, Witzenrath M, Tabeling C, Conrad ML.Clin Exp Allergy. 2020 Apr;50(4):520-531. doi: 10.1111/cea.13559. Epub 2020 Jan 28.

A SNP upstream of the cyclic GMP-AMP synthase (cGAS) gene protects from relapse and extra-pulmonary TB and relates to BCG vaccination status in an Indian cohort.

Thada S, Burkert S, Sivangala R, Hussain A, Sur S, Dittrich N, Conrad ML, Slevogt H, Latha Gaddam S, Schumann RR.Genes Immun. 2020 Jan;21(1):13-26. doi: 10.1038/s41435-019-0080-1. Epub 2019 May 23.

Recognition of microbial viability via TLR8 drives T_FH cell differentiation and vaccine responses.

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE.Nat Immunol. 2018 Apr;19(4):386-396. doi: 10.1038/s41590-018-0068-4. Epub 2018 Mar 19.

NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface.

Blois SM, Freitag N, Tirado-González I, Cheng SB, Heimesaat MM, Bereswill S, Rose M, Conrad ML, Barrientos G, Sharma S.Sci Rep. 2017 May 19;7(1):2189. doi: 10.1038/s41598-017-02333-8.